Source: http://news.feedzilla.com/en_us/stories/politics/top-stories/278998044?client_source=feed&format=rss
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Thursday, January 24, 2013
Studies provide insights into inherited causes of autism
Jan. 23, 2013 ? The most consistent finding of autism research lies in the revelation that the disorders are incredibly complex. Two new studies in the January 23 issue of the Cell Press journal Neuron that add to the growing appreciation of this complexity focus on identifying inherited genetic mutations linked with autism spectrum disorders. The mutations -- which are distinct from the spontaneous mutations that have been the focus of previous studies -- may provide valuable insights into the causes of autism.
"It's long been known that autism is a heritable condition and that some cases appear to run in families. Our studies are among the first to begin to address this heritable component," says Dr. Christopher Walsh of Boston Children's Hospital, who is the senior author of one of the papers.
Both groups sequenced the portion of the genome that codes for proteins, also known as the exome, in individuals with autism, their relatives, and controls. In one study, investigators focused on rare mutations that completely abolish the function of particular genes -- and therefore the expression of a protein. "We utilized new genome-sequencing technologies to discover a component of autism that can be traced to recessive inheritance -- that is, when a child inherits two broken copies of the same gene, one from each parent who is a carrier," explains senior author Dr. Mark Daly of Massachusetts General Hospital and the Broad Institute. "There were twice as many autism cases as control individuals that were apparently missing an important protein somewhere in the genome," he adds. Their findings suggest that 5% of autism risk is linked to inherited mutations that completely disrupt the functions of genes.
Like Dr. Daly and his colleagues, Dr. Walsh and his team identified and characterized cases of autism due to the inheritance of two gene mutations, one from each parent. In this work, though, the researchers found that the partial loss of a gene's function -- not only complete absence of function -- is linked to autism spectrum disorders. They identified several genes -- such as those involved in neurometabolic pathways -- that were not previously associated with autism risk, and they revealed a striking variability of autism severity despite inheritance of similar genetic mutations.
"These two studies firmly establish that recessive mutations contribute importantly to autism, not just in specialized populations but in the population at large," says first author Dr. Timothy Yu, of Boston Children's Hospital.
With follow-up work, identifying the various genes that are silent or partially disabled in autism cases can provide key clues to understanding the underlying biology of autism spectrum disorders and potentially help generate new therapies.
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The above story is reprinted from materials provided by Cell Press, via EurekAlert!, a service of AAAS.
Note: Materials may be edited for content and length. For further information, please contact the source cited above.
Journal References:
- Timothy?W. Yu, Maria?H. Chahrour, Michael?E. Coulter, Sarn Jiralerspong, Kazuko Okamura-Ikeda, Bulent Ataman, Klaus Schmitz-Abe, David?A. Harmin, Mazhar Adli, Athar?N. Malik, Alissa?M. D?Gama, Elaine?T. Lim, Stephan?J. Sanders, Ganesh?H. Mochida, Jennifer?N. Partlow, Christine?M. Sunu, Jillian?M. Felie, Jacqueline Rodriguez, Ramzi?H. Nasir, Janice Ware, Robert?M. Joseph, R.?Sean Hill, Benjamin?Y. Kwan, Muna Al-Saffar, Nahit?M. Mukaddes, Asif Hashmi, Soher Balkhy, Generoso?G. Gascon, Fuki?M. Hisama, Elaine LeClair, Annapurna Poduri, Ozgur Oner, Samira Al-Saad, Sadika?A. Al-Awadi, Laila Bastaki, Tawfeg Ben-Omran, Ahmad?S. Teebi, Lihadh Al-Gazali, Valsamma Eapen, Christine?R. Stevens, Leonard Rappaport, Stacey?B. Gabriel, Kyriacos Markianos, Matthew?W. State, Michael?E. Greenberg, Hisaaki Taniguchi, Nancy?E. Braverman, Eric?M. Morrow, Christopher?A. Walsh. Using Whole-Exome Sequencing to Identify Inherited Causes of Autism. Neuron, 2013; 77 (2): 259 DOI: 10.1016/j.neuron.2012.11.002
- Elaine?T. Lim, Soumya Raychaudhuri, Stephan?J. Sanders, Christine Stevens, Aniko Sabo, Daniel?G. MacArthur, Benjamin?M. Neale, Andrew Kirby, Douglas?M. Ruderfer, Menachem Fromer, Monkol Lek, Li Liu, Jason Flannick, Stephan Ripke, Uma Nagaswamy, Donna Muzny, Jeffrey?G. Reid, Alicia Hawes, Irene Newsham, Yuanqing Wu, Lora Lewis, Huyen Dinh, Shannon Gross, Li-San Wang, Chiao-Feng Lin, Otto Valladares, Stacey?B. Gabriel, Mark dePristo, David?M. Altshuler, Shaun?M. Purcell, Matthew?W. State, Eric Boerwinkle, Joseph?D. Buxbaum, Edwin?H. Cook, Richard?A. Gibbs, Gerard?D. Schellenberg, James?S. Sutcliffe, Bernie Devlin, Kathryn Roeder, Mark?J. Daly. Rare Complete Knockouts in Humans: Population Distribution and Significant Role in Autism Spectrum Disorders. Neuron, 2013; 77 (2): 235 DOI: 10.1016/j.neuron.2012.12.029
Note: If no author is given, the source is cited instead.
Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.
Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/rsLo94Tgfm8/130123133607.htm
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Wednesday, January 16, 2013
Jack Ma to stand down as Alibaba CEO, take back seat
HONG KONG (Reuters) - One of China's best known corporate leaders, Jack Ma, will step down as CEO of Alibaba Group, the e-commerce firm he founded in 1999 to tap the nation's enormous online shopping potential, saying younger people are better placed to run the company.
Ma said he would name a successor by May 10, when he switches to the role of executive chairman. He said most of Alibaba's leaders "born in the 1960s" would also pass their leadership responsibilities to younger colleagues.
"As a founder CEO, stepping down ... is a difficult decision. It's not because I wanted to take things easy (though the job of Alibaba CEO is no easy task), it's because I see that Alibaba's young people have better, more brilliant, dreams than mine, and they are more capable of building a future that belongs to them," Ma wrote in an e-mail to employees. Reuters obtained the letter on Tuesday from a source close to Alibaba.
The shift is a significant one for Alibaba and follows moves announced last week to chop the group into 25 smaller divisions ? to give managers more flexibility.
It also comes after a transformative deal Alibaba struck with Yahoo Inc last year, in which the Chinese company agreed to buy back about half of the stake in itself held by its U.S. partner. Alibaba had long sought to buy back the shares to help regain control over its own corporate destiny.
In an interview with The New York Times, 48-year-old Ma acknowledged he was feeling the strain. "When I was 35, I was so energetic and fresh-thinking. I had nothing to worry about," he said, adding the role of executive chairman would let him focus on broad strategic issues, as well as corporate development and social responsibility.
"I will still be very active," he said. "It is impossible for me to retire."
Alibaba Group includes Alibaba.com, an online market for small businesses; Taobao, a consumer shopping site; and Alipay, an online payment platform.
(Reporting by Lee Chyen Yee; Editing by Ian Geoghegan)
Source: http://news.yahoo.com/jack-ma-stand-down-alibaba-ceo-back-seat-095231440--sector.html
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Pulse; Facebook, Instagram, Flickr, Tumblr ve YouTube sosyal a?lar?n? da b?nyesine kat?yor
Mobil platformlar?n en pop?ler RSS okuma uygulamalar?ndan birisi olan Pulse, pek ?ok ?nemli haber kayna??n?n yan?na Facebook, Instagram, Flickr, Tumblr ve YouTube sosyal a?lar?n? da ekledi?ini duyurdu.
Yeni g?ncelleme ile eklenecek a?lar sayesinde kullan?c?lar sadece haber kaynaklar?n? de?il, sosyal a?lar?ndaki durum g?ncellemelerini ve payla??mlar? da tek elden takip etme olana??na kavu?acak.
Kullan?c?lar i?eirk ekleme men?s?nden Sosyal sekmesine giderek a?lar?n? ekleyebilecek. G?ncelleme ile ayr?ca yeni bir video ve foto?raf g?r?nt?leme aray?z? de ekleniyor. G?ncelleme hafta boyunca kullan?c?lara da??t?lacak.?
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Wednesday, January 9, 2013
Asking Our Elderly Parents for Help Can Be a ... - Elder Care ABC
by Kaye Swain
I love to feel needed, don?t you? One of the big issues for many of our aging parents is that, due to health problems, memory issues, and generation aging, they aren?t always able to do as much as they used to. This can leave them feeling very UNneeded, which can lead to depression.
I was reminded of this recently when chatting with other caregivers and realized I needed to be more proactive at finding ways to engage my senior mom with helping me, even if I didn?t necessarily ?need? it. This is something she truly desires and something my independent self tends to forget!
After racking my brains, I put together some ideas for her that might help you as well:
- Wash and dry dishes ? instead of automatically putting them in the dishwasher when we finish eating, it might work well to put them in the sink for them to load the dishwasher or, as my mom prefers, hand wash them.
- Fold laundry
- Mail coloring pages and letters to grandkids ? we go shopping at the Dollar Store and Walmart and my mom has such fun picking out coloring books, activity sheets, and stickers and mailing them along with little notes to her great-grandkids. I?ve gotten in the habit of bringing home extra ones to encourage her to do it even more often. She loves doing it, they thrill to all the extra mail, their mom appreciates the peace and quiet as they work on all the pretty pages, and all of these delightful activities are ?growing? such sweet and special family memories from this simple little tradition.
- If your aging parents like to garden, ask them to plant a couple of things for you. They?ll love spending the time working on a gift for you and you?ll enjoy the tasty treats that hopefully the plants will produce. (Be sure to take photos of the process every few days. I add those to my senior mom?s iPad and she gets to enjoy her garden again in the winter in between reading gardening books and magazines.)
- Wrap gifts. You may be able to wrap them faster and better ? but they may thoroughly enjoy the process as well as getting to be a help to you at busy holiday and birthday times.
- Ask them to call the long distance relatives and grandkids periodically and say hellos for you AND them.
- Give them all your old photos to sort and organize into folders. Not only can this be a big help for you, they will enjoy seeing all the pictures. (Hmmmm, I need to do this one ASAP!)
- Need ironing done? Do they enjoy ironing like my senior mom does? A win win for both of you!
- If they are still able to sew, see if they would like to hem your pants or sew buttons on. Or if they are good at crocheting and knitting, ask them to make simple projects ? for yourself or to donate to the many places that really need simple blankets, hats etc. ? like hospitals, police departments, etc.
Mind you, I?ve generally done all of these projects and chores myself. But as caregiving duties increase, not all of them get done in a timely manner. Delegating simple items to our senior parents can be a big help to us. Even more important, they can be a big spirit-lifter to them. And even if it doesn?t get done the way we normally do it, or needs to be surreptitiously re-done later, the smiles on their faces at being useful are well worth it. Do you have any more suggestions? We?d love to hear them.
Kaye Swain is a member of the Sandwich Generation dealing with the issues of caring for the elderly parents and relatives in her family while also babysitting grandchildren. She enjoys writing on those topics at SandwichINK, in order to provide other multigenerational caregivers with useful information, resources and encouragement.
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Source: http://eldercareabcblog.com/asking-our-elderly-parents-for-help-can-be-a-huge-gift-to-them/
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Tuesday, January 8, 2013
Colts' Arians returns to Indy after hospital stay
FILE -In this Sunday, Dec. 30, 2012 file photo, Indianapolis Colts offensive coordinator Bruce Arians watches during the first half of an NFL football game against the Houston Texans, in Indianapolis. Arians has been hospitalized with an illness Sunday, Jan. 6, 2012. (AP Photo/Darron Cummings, File)
FILE -In this Sunday, Dec. 30, 2012 file photo, Indianapolis Colts offensive coordinator Bruce Arians watches during the first half of an NFL football game against the Houston Texans, in Indianapolis. Arians has been hospitalized with an illness Sunday, Jan. 6, 2012. (AP Photo/Darron Cummings, File)
INDIANAPOLIS (AP) ? Colts offensive coordinator Bruce Arians returned to Indianapolis on Monday night after being released from a Baltimore hospital following a 36-hour stay for an undisclosed illness.
Team owner Jim Irsay told The Associated Press in a text message that Arians was accompanied by two team doctors, had been medicated and appeared to be on the mend.
"He was in good spirits (and) is trending (in) right direction," Irsay wrote.
Arians was admitted to the hospital Sunday morning after complaining he felt ill at the team breakfast. Without Arians, quarterbacks coach Clyde Christensen called the plays in the 24-9 season-ending loss to the Ravens.
Doctors ran a series of tests. Head coach Chuck Pagano acknowledged earlier Monday that although each of the tests was negative, the doctors decided to keep Arians in the hospital until his blood pressure stabilized.
"Whatever he's dealing with, they would have let him come home early this morning, but whatever he's dealing with affected his blood pressure and they're not going to release him until they get the blood pressure under control, which they will," Pagano said during a regularly-scheduled afternoon news conference.
The Colts couldn't wait to get Arians back in town.
They're next task is keeping him in the locker room ? though players and coaches believe Arians has done enough to warrant getting a head coaching job. It's a delicate balancing act for the Colts, who have given permission to at least two teams, Chicago and Philadelphia, to speak with Arians about their coaching vacancies.
There has been speculation that Cleveland and San Diego are also interested in Arians.
Teams seeking a younger, more image-conscious coach may not be interested in the 60-year-old Arians, who has a penchant for telling it like it is and in a folksy way. His only previous head-coaching experience came during a six-year tenure at Temple in the 1980s.
But it's hard to argue with the rest of his resume.
After Pagano was diagnosed with leukemia in September, Arians became the interim coach and guided the Colts to a 9-3 mark. That tied the NFL record for most victories after a midseason coaching change.
He mentored Peyton Manning, Tim Couch, Ben Roethlisberger and now Andrew Luck. He won two Super Bowls as an assistant in Pittsburgh, served on Paul "Bear" Bryant's staff at Alabama and has had a big part in two of the biggest turnarounds in NFL history ? the 10-game improvement of the 1999 Colts and Indy's nine-game improvement this year.
Clearly, the Colts (11-6) want him to come back, but they also understand why he's a hot commodity on the coaching carousel only one year after he was nearly forced into retirement.
"We do not want to lose Bruce," Pagano said. "He is so valuable to this organization and what he means to this organization and what he's done. You want the best for Bruce. I want the best for Bruce. I want the best for his family. I want him to achieve and reach any goals that he has for himself throughout his coaching years, things like that. It's a hard spot. Again, people are going to go after good people and this is just a byproduct of the success that we've had here."
Luck said he wants Arians back, too.
"Selfishly, I hope he doesn't go anywhere," Luck said before jokingly reiterating what he said last week ? that if teams asked him for a recommendation he would say terrible things about Arians to keep him in Indy.
He's not the only one at the team complex trying to do that.
"We will just use social media. We will get on the Internet, just like they do around draft time with all the players, all the baggage starts to come out," Pagano said, drawing laughter. "We won't do it here. We will just wait until later this evening, the next couple of weeks and start putting all that stuff out if it gets serious."
The likelihood is that those talks will get serious.
Arians has repeatedly told reporters in Indy that he will only leave for the right fit and that wherever he lands, he still wants to call the plays ? even if that means staying in Indy, where the entire offense would like to have him back for Year 2 of the Colts' reconstruction project.
"I want to be selfish but I can't," tight end Dwayne Allen said. "Bruce is such a great guy and what he did for us this year, the job as a head coach and an offensive coordinator was just unbelievable and he deserves an opportunity if he wants to. Hopefully he decides to stay with us because we'd love to have him but if we have to part ways, then so be it."
___
Online: http://pro32.ap.org/poll and http://twitter.com/AP_NFL
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Money Savings Tips for the New Year - Bankruptcy Windsor Ontario
Now that the holiday festivities are over and all the shopping is done and the presents unwrapped it may be time to make a New Year?s resolution about your personal finances. CIBC did a poll and found that Canadians have named paying down debt as their top financial priority entering into 2013. This year why not make a few changes to improve your finances. They say changes happen in small steps and many times New Year?s resolutions fail because we make goals that seem unattainable and we don?t know how to ?eat the elephant one bite at a time?. Let?s start small.
Here are some money saving tips for 2013:
v Take an inventory of your personal finance. Use a computer program or even a simple three column ledger and record all your monthly bills and your income. Get a clear picture on your spending and use the information to make up a budget that manages your spending habits.
v Shop & Wait ? If you have the impulse to buy something, wait 48 hours and see if it?s still there or if you still want it.
v Saving electricity ? When leaving your house for the evening, never leave on more than two lights as saving electricity means saving money.
v Drink coffee at home and limit the amount you spend out buying coffee. My husband and I bought a Keurig and it has saved us money on a monthly basis and you can buy a variety of flavoured coffee, tea and hot chocolate. Also bring a thermos to work for throughout the day.
v If your kids keep their marks up in school, then treat them in the off-season for vacation as it is cheaper than peak season.
v Use cruise control on the highway when you can as it improves fuel and saves money.
v Always BYO lunch to work and you will save $5 a day.
v Decide how much money you want to spend next Christmas on each person and divide by 12months and start saving money in the bank. This way when you start shopping in November and December you actually have the money in the bank instead of buying on credit. Remember you can give without having a negative checking account.
v Don?t shop for groceries on an empty stomach as you will most likely buy more than you need.
v Buy some groceries, you regularly use, in bulk when on sale.
v Work out a budget and create a shopping list based only on what you can afford. Also when you make a list it will reduce the temptation to buy items on the spur of the moment which you don?t really need.
If after trying some (or all) of these tips to save money you are still having a hard time making ends meets, then give me a call at 519-250-8060 and I can show you how you can be ?debt free in 30?.
Source: http://www.bankruptcy-windsor.com/bankruptcy/2013/01/money-savings-tips-for-the-new-year.html
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